‘Lighting up’ inflammation: New technologies to track inflammation
New molecular and genetically-encoded fluorescent probes and biosensors are being developed to track the migration and status of inflammatory cells and mediators, to enhance detection and monitoring of inflammatory processes in specific organs and to accelerate drug development. This toolbox of molecules, cells and gene-modified animals will used by CIDR, as well as the wider inflammation research community, to understand pathological processes and inflammatory targets in animal models of human inflammatory diseases. The aim is to lead to new approaches for diagnosis of inflammation-related diseases.
Inflammation discovery: New players in pathology
Knowledge of molecular mechanisms for cell activation, recruitment and secretion of inflammatory mediators provides new insights into how inflammation is normally regulated and how it is dysregulated in disease. We study receptors, signalling pathways, intracellular enzymes and secreted proteins involved in inflammation. We aim to validate novel genes, proteins and pathways as drivers or biomarkers of unhealthy inflammation.
Inflammation translation: New drugs to turn inflammation on and or off
New insights into mechanisms of inflammation are enabling us to discover new drug targets and therapies, and to repurpose existing drugs, for the treatment of chronic inflammatory diseases including some diseases not previously known to have an inflammatory origin. We aim to develop new chemical entities with novel anti-inflammatory drug profiles. These may ultimately lead to new therapeutic approaches for inflammation-related diseases.