Inflammation is a coordinated set of protective responses to infection, injury and/or disturbances in normal human physiology. Uncontrolled inflammation contributes to the progression of many diseases, including inflammatory bowel diseases, sepsis, fatty liver disease, asthma, arthritis, obesity, type 2 diabetes, cardiovascular and neurodegenerative diseases, and cancers. For some of these conditions, diagnosis is not sensitive enough or occurs too late, and treatment often brings only symptomatic relief without halting the underlying pathological processes.
To tackle this growing problem, IMB’s Centre for Inflammation and Disease Research (CIDR) is identifying pathways in the body that control inflammation, and is developing innovative new approaches to track the progression from protective to pathological inflammation. This will help us to develop new therapies and drugs to treat and prevent the underlying causes of many inflammation-related diseases.